Research Paper Volume 13, Issue 3 pp 4522—4551

Hsa_circ_0000199 facilitates chemo-tolerance of triple-negative breast cancer by interfering with miR-206/613-led PI3K/Akt/mTOR signaling

MiR-613 and miR-206 were involved in modulating contribution of hsa

Figure 5. MiR-613 and miR-206 were involved in modulating contribution of hsa_circ_0000199 to activity of triple-negative breast cancer (TNBC) cells. (A, B) Proliferation of MDA-MB-231 and MDA-MB-468 cell lines were compared after treatments of si-hsa_circ_0000199+miR-613/miR-206 inhibitor, si-hsa_circ_0000199 and none. *: compared with NC group; #: compared with si-hsa_circ_0000199 group; **/##: P<0.01; ***/###: P<0.001. (C, D) Migration of MDA-MB-231 and MDA-MB-468 cell lines were appraised among si-hsa_circ_0000199+miR-613/miR-206 inhibitor, si-hsa_circ_0000199 and NC groups. **: P<0.01; ***: P<0.001. (E, F) The invasive capability of MDA-MB-231 and MDA-MB-468 cell lines were evaluated after treatments of si-hsa_circ_0000199+miR-613/miR-206 inhibitor, si-hsa_circ_0000199 and none. ***: P<0.001.