Research Paper Volume 13, Issue 3 pp 4590—4604

Decreased miR-132 plays a crucial role in diabetic encephalopathy by regulating the GSK-3β/Tau pathway

Low miR-132 expression in DE rat hippocampal tissues and injured HT-22 cells. (A) The expression levels of 10 different miRs in primary hippocampal neurons based on the qRT-PCR analysis. (B) The expression levels of 10 different miRs in hippocampal tissues based on the qRT-PCR analysis. *, **, and *** means P C) There is a significant difference of miR-132 between the CG and DM groups, as well as the DE group in hippocampal tissues (P D) The relative expression levels of miR-132 are lower in primary hippocampal neurons treated with mannitol, high glucose, and H2O2 compared to the control group. Data are presented as the mean ± SD (n = 3 per group). * P P

Figure 2. Low miR-132 expression in DE rat hippocampal tissues and injured HT-22 cells. (A) The expression levels of 10 different miRs in primary hippocampal neurons based on the qRT-PCR analysis. (B) The expression levels of 10 different miRs in hippocampal tissues based on the qRT-PCR analysis. *, **, and *** means P < 0.05, < 0.01, < 0.001 vs Con; n =3 for each group. (C) There is a significant difference of miR-132 between the CG and DM groups, as well as the DE group in hippocampal tissues (P < 0.01). (D) The relative expression levels of miR-132 are lower in primary hippocampal neurons treated with mannitol, high glucose, and H2O2 compared to the control group. Data are presented as the mean ± SD (n = 3 per group). * P < 0.01 vs. control group, ** P < 0.05 vs. the control group, n =3 for each group.