Research Paper Volume 13, Issue 3 pp 4605—4616

Resveratrol alleviates bleomycin-induced pulmonary fibrosis via suppressing HIF-1α and NF-κB expression

Resveratrol reverses bleomycin-induced pulmonary fibrosis in vivo. (A) Administration of resveratrol to establish bleomycin-induced pulmonary fibrosis model in rat. (B) Gross views of the lungs on days 7, 14, and 28 following different treatments. Data are expressed as mean ± standard deviation (SD) of three independent experiments. *p p p p C) The results of hematoxylin and eosin (H&E) staining of samples obtained from the lungs on days 7, 14, and 28 following different treatments (scale bar = 200 μm).

Figure 1. Resveratrol reverses bleomycin-induced pulmonary fibrosis in vivo. (A) Administration of resveratrol to establish bleomycin-induced pulmonary fibrosis model in rat. (B) Gross views of the lungs on days 7, 14, and 28 following different treatments. Data are expressed as mean ± standard deviation (SD) of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. (C) The results of hematoxylin and eosin (H&E) staining of samples obtained from the lungs on days 7, 14, and 28 following different treatments (scale bar = 200 μm).