Figure 2. Prediction of miR-16-5p and miR-21-5p target genes and their biological functions. (A) Venn Diagram of the common target genes of miR-16-5p and miR-21-5p predicted by TargetScan, miRWalk and miRDB. (B) Protein-protein interaction (PPI) network of miR-21-5p and miR-16-5p target genes. (C) Top 15 hub target genes identified by the Cytohubba plug-in of Cytoscape. (D) Three key modules of the PPI network identified by the MCODE plug-in of Cytoscape. (E) Function analysis of all target genes in three modules. FDR, false discovery rate.