Figure 5. Exo-si-FAM138B promoted HCC growth by promoting miR-765. (A) Cancer cells was transfected with si-FAM138B or NC, and exosomes were isolated. The expression of linc-FAM138B in exosomes was determined. SK-HEP-1 and HepG2 cells were incubated with isolated exosomes, and then were transfected with AMO-765 or AMO-NC. (B) The expression of linc-FAM138B in SK-HEP-1 and HepG2 cells was evaluated. (C) The level of miR-765 in SK-HEP-1 and HepG2 cells was detected. (D). MTT assay for cell proliferation of SK-HEP-1 and HepG2 cells. (E, F). Wound healing assay for cell migration of SK-HEP-1 and HepG2 cells. Scale bar, 60 μm. (G, H). Transwell assay for cell invasion of SK-HEP-1 and HepG2 cells. Scale bar, 60 μm. Data are mean ± SD; *P < 0.05 vs exo-linc-FAM138B+NC. Data among multiple groups were analyzed by one-way ANOVA, followed by a Tukey post hoc test. The experiment was repeated in triplicate.