Research Paper Volume 13, Issue 4 pp 5369—5382

Inhibiting TLR4 signaling by linarin for preventing inflammatory response in osteoarthritis

Influence of Linarin in LPS-induced inflammatory reaction in human chondrocytes. (A, B) iNOS and COX-2 protein level in chondrocytes measured by western blot. (C) Effect of Linarin on LPS-exposed IL-6, TNF-α, PGE2, and NO production in human chondrocytes. The data in the figures represent the averages ± S.D. Significant differences among different groups are indicated as ##P P

Figure 2. Influence of Linarin in LPS-induced inflammatory reaction in human chondrocytes. (A, B) iNOS and COX-2 protein level in chondrocytes measured by western blot. (C) Effect of Linarin on LPS-exposed IL-6, TNF-α, PGE2, and NO production in human chondrocytes. The data in the figures represent the averages ± S.D. Significant differences among different groups are indicated as ##P < 0.01, vs. control group; **P < 0.01 vs. LPS alone treatment group, n=5.