Research Paper Volume 13, Issue 4 pp 5553—5570

Melatonin protects against defects induced by Enniatin B1 during porcine early embryo development

Effect of melatonin on DNA methylation statuses of genome and pluripotent genes in EB1-exposed embryos. (A–D) DNA methylation statuses of genome (CenRep), Oct4, Nanog and Sox2, respectively. CON, the control group. EB1, embryos treated with EB1. MT, embryos treated with melatonin. ME, embryos treated with both melatonin and EB1. The black and white circles are the methylated and unmethylated CpG sites, respectively, and the gray circles represent the mutated and/or single nucleotide polymorphism (SNP) variation at the certain CpG sites.

Figure 7. Effect of melatonin on DNA methylation statuses of genome and pluripotent genes in EB1-exposed embryos. (AD) DNA methylation statuses of genome (CenRep), Oct4, Nanog and Sox2, respectively. CON, the control group. EB1, embryos treated with EB1. MT, embryos treated with melatonin. ME, embryos treated with both melatonin and EB1. The black and white circles are the methylated and unmethylated CpG sites, respectively, and the gray circles represent the mutated and/or single nucleotide polymorphism (SNP) variation at the certain CpG sites.