COVID-19 Research Paper Volume 13, Issue 4 pp 4794—4810

Association of D-dimer elevation with inflammation and organ dysfunction in ICU patients with COVID-19 in Wuhan, China: a retrospective observational study

Dynamic changes in organ function in patients with different D-dimer levels within 14 days after ICU admission. (A) liver injury (B) kidney injury (C) myocardial injury (D) severe ARDS (E) thrombocytopenia (F) DIC (ISTH criteria), D1: 1.5≤D-dimer▼P#P##P

Figure 3. Dynamic changes in organ function in patients with different D-dimer levels within 14 days after ICU admission. (A) liver injury (B) kidney injury (C) myocardial injury (D) severe ARDS (E) thrombocytopenia (F) DIC (ISTH criteria), D1: 1.5≤D-dimer<10μg/mL, D2: 10≤D-dimer<40μg/mL, D3: D-dimer≥40μg/mL. P<0.05 with D1 group vs. D2 group, #P<0.05, ##P<0.01 with D2 group vs. D3 group, *P<0.05, **P<0.01 with D1 group vs. D3 group. ARDS: acute respiratory distress syndrome, DIC: disseminated intravascular coagulation, ISTH: international society of thrombosis and hemostasis.