Research Paper Volume 13, Issue 4 pp 5718—5747

Comprehensive analysis of macrophage-related multigene signature in the tumor microenvironment of head and neck squamous cancer

Correlation between the level of FANCE expression and immune infiltration in HNSC obtained from the TIMER database (<a href="https://cistrome.shinyapps.io/timer/" target="

Figure 10. Correlation between the level of FANCE expression and immune infiltration in HNSC obtained from the TIMER database (https://cistrome.shinyapps.io/timer/). (A) FANCE expression was significantly negatively correlated with infiltration of CD4+ T cells, macrophages, neutrophils, and dendritic cells in HNSC. Tumor purity and FANCE were found to have a significant positive correlation, while B cell and CD8 + T cell infiltration levels and FANCE expression were not significantly correlated. (B, C) Similar negative correlations were observed with the level of infiltrating lymphocytes in HPV-negative HNSC samples, but no significant correlation was found in HPV-positive patients.