Research Paper Volume 13, Issue 4 pp 5718—5747

Comprehensive analysis of macrophage-related multigene signature in the tumor microenvironment of head and neck squamous cancer

Correlation analysis between FANCE and macrophage marker genes in cBioportal (<a href="https://www.cbioportal.org/" target="

Figure 13. Correlation analysis between FANCE and macrophage marker genes in cBioportal (https://www.cbioportal.org/). (A) TAM marker genes, including CCL2, CD68 and IL10, have a significant negative correlation with FANCE (all *P<0.05). (B) IRF5, NOS2 and PTGS2 are marker genes of M1 macrophages. There was a significantly positive co-expression of FANCE and NOS2 (*P= 1.204×10-4), but no significant co-expression relationship was found in IRF5 and PTGS2. (C) Marker genes of M2 macrophages, including CD163, MS4A4A and VSIG4, had a significant negative correlation with FANCE (all *P<0.05).