Research Paper Volume 13, Issue 4 pp 5718—5747

Comprehensive analysis of macrophage-related multigene signature in the tumor microenvironment of head and neck squamous cancer

GSEA identifies a FANCE-related signaling pathway. Cell cycle, DNA repair, and apoptosis signaling pathways are differentially enriched in the high FANCE expression phenotype. Immunoglobulin binding, monocyte chemotaxis and regulation of macrophage cytokine production are enriched in the FANCE down-regulation phenotype.

Figure 8. GSEA identifies a FANCE-related signaling pathway. Cell cycle, DNA repair, and apoptosis signaling pathways are differentially enriched in the high FANCE expression phenotype. Immunoglobulin binding, monocyte chemotaxis and regulation of macrophage cytokine production are enriched in the FANCE down-regulation phenotype.