Research Paper Volume 13, Issue 4 pp 5804—5823

Macrophage migration inhibitory factor activates the inflammatory response in joint capsule fibroblasts following post-traumatic joint contracture

Inhibition of MIF in the lesion area attenuated posterior joint capsule inflammation and fibrosis. (A) Expression of MIF (red) in the posterior joint capsule was assessed via immunostaining at 0 d, 3 d and 3 d after injection of 4-IPP. (B) Immunostaining of CD68-positive macrophages (green) in the posterior joint capsule. (C) HE staining of the posterior joint capsule. (D) Masson staining of the posterior joint capsule. Scale bars, 20 μm.

Figure 4. Inhibition of MIF in the lesion area attenuated posterior joint capsule inflammation and fibrosis. (A) Expression of MIF (red) in the posterior joint capsule was assessed via immunostaining at 0 d, 3 d and 3 d after injection of 4-IPP. (B) Immunostaining of CD68-positive macrophages (green) in the posterior joint capsule. (C) HE staining of the posterior joint capsule. (D) Masson staining of the posterior joint capsule. Scale bars, 20 μm.