Research Paper Volume 13, Issue 4 pp 5946—5966

Multi-omics analysis identifies potential mechanisms of AURKB in mediating poor outcome of lung adenocarcinoma

AURKB could independently predict the survival of lung adenocarcinoma. (A) AURKB expression distribution in all tumor samples; (B) High AURKB expression led to worse overall survival in the TCGA-LUAD cohort (HR[95%CI]: 1.593[1.18-2.14], p = 0.002). (C) High AURKB expression correlated with poor progression-free survival in the TCGA-LUAD cohort (HR[95%CI]: 1.415[1.07-1.86], p = 0.013). (D) Multivariate analysis showed AURKB and N stage were independent prognosis factor in the TCGA-LUAD cohort (HR[95%CI]: 1.672[1.045-2.674], 1.897[1.13-3.184], respectively). (E) Meta-analysis of AURKB expression in the prediction of overall survival of lung adenocarcinoma patients from different datasets by Lung Cancer Explorer (LCE).

Figure 2. AURKB could independently predict the survival of lung adenocarcinoma. (A) AURKB expression distribution in all tumor samples; (B) High AURKB expression led to worse overall survival in the TCGA-LUAD cohort (HR[95%CI]: 1.593[1.18-2.14], p = 0.002). (C) High AURKB expression correlated with poor progression-free survival in the TCGA-LUAD cohort (HR[95%CI]: 1.415[1.07-1.86], p = 0.013). (D) Multivariate analysis showed AURKB and N stage were independent prognosis factor in the TCGA-LUAD cohort (HR[95%CI]: 1.672[1.045-2.674], 1.897[1.13-3.184], respectively). (E) Meta-analysis of AURKB expression in the prediction of overall survival of lung adenocarcinoma patients from different datasets by Lung Cancer Explorer (LCE).