Figure 6. Tumor suppressors (DLC1 and HLF) negatively correlated with AURKB and its associated miRNAs and methylation modification. (A) Venn plot of identified DEGs, differentially expressed microRNAs, and DMRs; (B) the expression levels (Log2(TPM+1)) of AURKB, DLC1, and HLF in paired tumor and adjacent tissues in the TCGA-LUAD cohort. (C) The correlation of HLF or DLC1 with AURKB were analyzed by GEPIA website (HLF: R = -0.29, p = 4.1e-11; DLC1: R = -0.31, p = 5.8e-12). (D) Low expression of DLC1 or HLF led to poor overall survival in the TCGA-LUAD cohort (p = 0.078, 0.0029, respectively). (E) Meta-analysis of DLC1 or HLF expression in the prediction of overall survival in lung adenocarcinoma patients from different datasets by lung cancer explorer (LCE).