Research Paper Volume 13, Issue 4 pp 5946—5966

Multi-omics analysis identifies potential mechanisms of AURKB in mediating poor outcome of lung adenocarcinoma

Tumor suppressors (DLC1 and HLF) negatively correlated with AURKB and its associated miRNAs and methylation modification. (A) Venn plot of identified DEGs, differentially expressed microRNAs, and DMRs; (B) the expression levels (Log2(TPM+1)) of AURKB, DLC1, and HLF in paired tumor and adjacent tissues in the TCGA-LUAD cohort. (C) The correlation of HLF or DLC1 with AURKB were analyzed by GEPIA website (HLF: R = -0.29, p = 4.1e-11; DLC1: R = -0.31, p = 5.8e-12). (D) Low expression of DLC1 or HLF led to poor overall survival in the TCGA-LUAD cohort (p = 0.078, 0.0029, respectively). (E) Meta-analysis of DLC1 or HLF expression in the prediction of overall survival in lung adenocarcinoma patients from different datasets by lung cancer explorer (LCE).

Figure 6. Tumor suppressors (DLC1 and HLF) negatively correlated with AURKB and its associated miRNAs and methylation modification. (A) Venn plot of identified DEGs, differentially expressed microRNAs, and DMRs; (B) the expression levels (Log2(TPM+1)) of AURKB, DLC1, and HLF in paired tumor and adjacent tissues in the TCGA-LUAD cohort. (C) The correlation of HLF or DLC1 with AURKB were analyzed by GEPIA website (HLF: R = -0.29, p = 4.1e-11; DLC1: R = -0.31, p = 5.8e-12). (D) Low expression of DLC1 or HLF led to poor overall survival in the TCGA-LUAD cohort (p = 0.078, 0.0029, respectively). (E) Meta-analysis of DLC1 or HLF expression in the prediction of overall survival in lung adenocarcinoma patients from different datasets by lung cancer explorer (LCE).