Research Paper Volume 13, Issue 5 pp 6662—6680

The novel roles of virus infection-associated gene CDKN1A in chemoresistance and immune infiltration of glioblastoma

CDKN1A and p-CDKN1A were highly expressed in TMZ-resistant glioma cells. (A, B) Compared with U87 cells, U87-R cells were significantly more resistant to the therapy of TMZ by using the colony formation assay. (C, D) Compared with T98G cells, T98G-R cells were significantly more resistant to the therapy of TMZ by using the colony formation assay. (E–G) Compared with U87 and T98G cells, the protein expression levels of CDKN1A and p-CDKN1A were significantly higher in U87-R and T98G-R cells, respectively. The results were presented as means ± SD (n = 3 for each panel). Statistical significance was concluded at *P

Figure 5. CDKN1A and p-CDKN1A were highly expressed in TMZ-resistant glioma cells. (A, B) Compared with U87 cells, U87-R cells were significantly more resistant to the therapy of TMZ by using the colony formation assay. (C, D) Compared with T98G cells, T98G-R cells were significantly more resistant to the therapy of TMZ by using the colony formation assay. (EG) Compared with U87 and T98G cells, the protein expression levels of CDKN1A and p-CDKN1A were significantly higher in U87-R and T98G-R cells, respectively. The results were presented as means ± SD (n = 3 for each panel). Statistical significance was concluded at *P < 0.05.