Research Paper Volume 13, Issue 4 pp 6010—6024

Exosomal long non-coding RNA LINC00662 promotes non-small cell lung cancer progression by miR-320d/E2F1 axis

Exosomal LINC00662 promotes the progression of NSCLC by miR-320d/E2F1 axis in vitro. (A–F) The HCC827 and A549 cells were treated with LINC00662 overexpression vector, or co-treated with LINC00662 overexpression vector and miR-320d mimic or lentiviral plasmids carrying E2F1 shRNA. (A, B) The cell viability was analyzed by the MTT assays in the cells. (C, D) The cell apoptosis was measure by flow cytometry analysis in the cells. (E, F) The cell migration and invasion were examined by transwell assays in the cells. Data are presented as mean ± SD. Statistic significant differences were indicated: * P P

Figure 6. Exosomal LINC00662 promotes the progression of NSCLC by miR-320d/E2F1 axis in vitro. (AF) The HCC827 and A549 cells were treated with LINC00662 overexpression vector, or co-treated with LINC00662 overexpression vector and miR-320d mimic or lentiviral plasmids carrying E2F1 shRNA. (A, B) The cell viability was analyzed by the MTT assays in the cells. (C, D) The cell apoptosis was measure by flow cytometry analysis in the cells. (E, F) The cell migration and invasion were examined by transwell assays in the cells. Data are presented as mean ± SD. Statistic significant differences were indicated: * P < 0.05, ** P < 0.01.