Research Paper Volume 13, Issue 5 pp 6681—6701

Indoxyl sulfate caused behavioral abnormality and neurodegeneration in mice with unilateral nephrectomy

Indoxyl sulfate caused alterations in unilateral nephrectomized mice. The intact and unilateral nephrectomized (1/2-Nephrectomy) mice were intraperitoneally injected with various doses of indoxyl sulfate (IS) for 7 weeks. A FST was conducted for a period of 5 minutes and the duration of immobility was recorded (A). A TST was performed for a period of 6 minutes and the duration of immobility was recorded (B). *p

Figure 2. Indoxyl sulfate caused alterations in unilateral nephrectomized mice. The intact and unilateral nephrectomized (1/2-Nephrectomy) mice were intraperitoneally injected with various doses of indoxyl sulfate (IS) for 7 weeks. A FST was conducted for a period of 5 minutes and the duration of immobility was recorded (A). A TST was performed for a period of 6 minutes and the duration of immobility was recorded (B). *p < 0.05 vs. intact control group without indoxyl sulfate, n = 5.