Research Paper Volume 13, Issue 5 pp 6681—6701

Indoxyl sulfate caused behavioral abnormality and neurodegeneration in mice with unilateral nephrectomy

Peripheral indoxyl sulfate treatment increased its blood and CNS distribution. Unilateral nephrectomized mice were intraperitoneally injected with indoxyl sulfate (IS, 0 and 100 mg/kg) and the indoxyl sulfate-injected mice were orally given with AST-120 (0 and 400 mg/kg) for 7 weeks. The blood (A), prefrontal cortical tissue (B), and CSF (C) were isolated and subjected to the measurement of indoxyl sulfate. *p

Figure 3. Peripheral indoxyl sulfate treatment increased its blood and CNS distribution. Unilateral nephrectomized mice were intraperitoneally injected with indoxyl sulfate (IS, 0 and 100 mg/kg) and the indoxyl sulfate-injected mice were orally given with AST-120 (0 and 400 mg/kg) for 7 weeks. The blood (A), prefrontal cortical tissue (B), and CSF (C) were isolated and subjected to the measurement of indoxyl sulfate. *p < 0.05 vs. control group, and #p < 0.05 vs. indoxyl sulfate alone (IS) group, n = 8.