Research Paper Volume 13, Issue 5 pp 6330—6345

Age-dependent remodeling of gut microbiome and host serum metabolome in mice

Top metabolic alterations in aging. (A, B) Guanosine and allantoin, metabolites in the purine metabolism pathway. (C, D) Hydroxyproline and N-acetylornithine, metabolites in the arginine and proline metabolism pathway. (E, F) Erythrose phosphate and nicotinamide, metabolites in the pentose phosphate and nicotinamide pathways, respectively. n=4, 5, 4 and 4 for the 3-, 12-, 18- and 28 months old (3M, 12M, 18M, 28M) groups, respectively.

Figure 4. Top metabolic alterations in aging. (A, B) Guanosine and allantoin, metabolites in the purine metabolism pathway. (C, D) Hydroxyproline and N-acetylornithine, metabolites in the arginine and proline metabolism pathway. (E, F) Erythrose phosphate and nicotinamide, metabolites in the pentose phosphate and nicotinamide pathways, respectively. n=4, 5, 4 and 4 for the 3-, 12-, 18- and 28 months old (3M, 12M, 18M, 28M) groups, respectively.