Research Paper Volume 13, Issue 2 pp 1686—1691

Shorter telomeres in children with severe asthma, an indicative of accelerated aging

Shorter telomeres in STRA children. (A) Relative telomere length (rTL) measured in whole blood from HC (n=126), MA (n=124) and STRA (n=17). (B) Augmented levels of eotaxin-1 in STRA children (n=16) compared to HC (n=24) and MA (n=24). (C) Eotaxin-1 is inversely correlated with rTL only in the STRA group. Data presented as [median; IQR (25-75)]. Kruskal-Wallis test followed by Dunn's multiple comparisons and Pearson correlation test. Significant differences were considered when pp

Figure 1. Shorter telomeres in STRA children. (A) Relative telomere length (rTL) measured in whole blood from HC (n=126), MA (n=124) and STRA (n=17). (B) Augmented levels of eotaxin-1 in STRA children (n=16) compared to HC (n=24) and MA (n=24). (C) Eotaxin-1 is inversely correlated with rTL only in the STRA group. Data presented as [median; IQR (25-75)]. Kruskal-Wallis test followed by Dunn's multiple comparisons and Pearson correlation test. Significant differences were considered when p<0.05 (*); p<0.01 (**). NS: non-significant.