Research Paper Volume 13, Issue 5 pp 6752—6764

Extracellular vesicle-encapsulated microRNA-23a from dorsal root ganglia neurons binds to A20 and promotes inflammatory macrophage polarization following peripheral nerve injury

The scheme illustrates the mechanism of action of miR-23a in the nerve injury and pain initiation. Sensory neuron-derived EVs-encapsulated miR-23a exacerbates neuropathic pain and promotes M1 polarization of macrophages in peripheral nerve injury by inhibiting A20 and activating the NF-κB signaling.

Figure 7. The scheme illustrates the mechanism of action of miR-23a in the nerve injury and pain initiation. Sensory neuron-derived EVs-encapsulated miR-23a exacerbates neuropathic pain and promotes M1 polarization of macrophages in peripheral nerve injury by inhibiting A20 and activating the NF-κB signaling.