Figure 6. SIRT6 protects LFH cells from DNA damage and telomere dysfunction via activation of telomerase activity. (A) Representative images of LF cells stained for γH2AX (red) and TRF-1 (green) and counterstained with DAPI (blue). Scale bar = 5 μm. The mean number of γH2AX foci (B), TRF-1 (C) and telomere dysfunction-induced foci (TIFs, D) in cells were quantified using ImageJ. Data are means ± SD of three replicates. *p<0.05, **p<0.01 vs. LFN. #p<0.05 vs. LFH control.