Research Paper Volume 13, Issue 5 pp 6804—6819

Transcription factor ELK1 accelerates aerobic glycolysis to enhance osteosarcoma chemoresistance through miR-134/PTBP1 signaling cascade

The mechanism graph of transcription factor ELK1 in chemoresistance in osteosarcoma. ELK1 promotes aerobic glycolysis by inhibiting miR-134 and upregulating PTBP1 expression, thus enhancing chemotherapeutic resistance in osteosarcoma.

Figure 8. The mechanism graph of transcription factor ELK1 in chemoresistance in osteosarcoma. ELK1 promotes aerobic glycolysis by inhibiting miR-134 and upregulating PTBP1 expression, thus enhancing chemotherapeutic resistance in osteosarcoma.