Resveratrol improves Gly-LDL-induced vascular endothelial cell apoptosis, inflammatory factor secretion and oxidative stress by regulating miR-142-3p and regulating SPRED2-mediated autophagy

Wenjun Sha; Meizhi Liu; Dusang Sun; Junhui Qiu; Bilin Xu; Lin Chen; Tian Shen; Cheng Chen; Hongping Wang; Cuiping Zhang; Tao Lei

doi:doi:10.18632/aging.202546

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Research Paper Volume 13, Issue 5 pp 6878—6889

Resveratrol improves Gly-LDL-induced vascular endothelial cell apoptosis, inflammatory factor secretion and oxidative stress by regulating miR-142-3p and regulating SPRED2-mediated autophagy

Figure 1. Resveratrol inhibits the high expression of miR-142-3p in HUVEC induced by Gly-LDL in a dose-dependent manner, and promotes SPRED2 expression and cell proliferation. (A) Cell viability of each group was tested by MTT. (B) The expression of miR-142-3p in all groups by PCR. (C) The expression of SPRED2 in all groups by western blotting. (D) The expression of SPRED2 in all groups by western blotting. *, P < 0.05; **, P < 0.01; ***, P < 0.001.