Research Paper Volume 13, Issue 5 pp 6918—6935

LncRNA Sirt1-AS upregulates Sirt1 to attenuate aging related deep venous thrombosis

Sirt1 activation suppresses DVT in SAMP-1 mice. (A) HE staining of endothelia in different groups of SAMP-1 mice (40*). (B–D) mRNA and protein expression of P-selectin, PSGL-1 and vWF in different groups of SAMP-1 mice. (E–H) The rate of thrombus, length and wet weight of thrombus in different groups of SAMP-1 mice. (I, J) mRNA expression of senescence associated genes Icam1 and Serpine1. Error bars represent SD. *, p

Figure 3. Sirt1 activation suppresses DVT in SAMP-1 mice. (A) HE staining of endothelia in different groups of SAMP-1 mice (40*). (BD) mRNA and protein expression of P-selectin, PSGL-1 and vWF in different groups of SAMP-1 mice. (EH) The rate of thrombus, length and wet weight of thrombus in different groups of SAMP-1 mice. (I, J) mRNA expression of senescence associated genes Icam1 and Serpine1. Error bars represent SD. *, p< 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.