Research Paper Volume 13, Issue 5 pp 6945—6956

Silencing of miR-483-5p alleviates postmenopausal osteoporosis by targeting SATB2 and PI3K/AKT pathway

SATB2 is a direct target gene of miR-483-5p. (A) The predicted sites of miR-483-5p binding to the 3’-UTR of SATB2. (B) Luciferase activity was measured in miR-483-5p mimic transfected MC3T3-E1 cells. (C) Luciferase activity was measured in miR-483-5p inhibitor transfected MC3T3-E1 cells. Data were presented as mean ± SD. a p

Figure 2. SATB2 is a direct target gene of miR-483-5p. (A) The predicted sites of miR-483-5p binding to the 3’-UTR of SATB2. (B) Luciferase activity was measured in miR-483-5p mimic transfected MC3T3-E1 cells. (C) Luciferase activity was measured in miR-483-5p inhibitor transfected MC3T3-E1 cells. Data were presented as mean ± SD. a p < 0.05 versus negative control (NC).