Research Paper Volume 13, Issue 5 pp 6945—6956

Silencing of miR-483-5p alleviates postmenopausal osteoporosis by targeting SATB2 and PI3K/AKT pathway

Inhibition of PI3K/AKT pathway reversed the effect of miR-483-5p on osteoporosis. (A) Western blotting results of the indicators of osteogenic differentiation in MC3T3-E1 cells. (B) Quantitative analysis of the optical density in (A). (C) Western blotting results of PI3K/AKT and GSK3β/β-catenin pathway in MC3T3-E1 cells. (D) Quantitative analysis of the optical density in (C). Data were presented as mean ± SD. a p b p

Figure 5. Inhibition of PI3K/AKT pathway reversed the effect of miR-483-5p on osteoporosis. (A) Western blotting results of the indicators of osteogenic differentiation in MC3T3-E1 cells. (B) Quantitative analysis of the optical density in (A). (C) Western blotting results of PI3K/AKT and GSK3β/β-catenin pathway in MC3T3-E1 cells. (D) Quantitative analysis of the optical density in (C). Data were presented as mean ± SD. a p < 0.05 versus control group, b p < 0.05 versus mimic group.