Research Paper Volume 13, Issue 7 pp 9522—9541

EGB761 ameliorates chronic cerebral hypoperfusion-induced cognitive dysfunction and synaptic plasticity impairment

EGB761 could inhibit axons demyelination after CCH. Under the ultramicrotomed sections, the axons and their myelination was observed (A) (Bar scale= 1μm) and diameter of axonal fiber and total diameter of axon (axonal fiber myelin sheath) were measured. g-ratio (diameter of axonal fiber / total diameter of axon) and percentage of myelinated axons were calculated (n=3 for 4 group) (B, C). MBP and β-actin in brain homogenates were assayed by Western blotting (D, E) (Con: n=4; 2VO: n=5; 2VO+EGB761: n=6; EGB761: n=5).

Figure 7. EGB761 could inhibit axons demyelination after CCH. Under the ultramicrotomed sections, the axons and their myelination was observed (A) (Bar scale= 1μm) and diameter of axonal fiber and total diameter of axon (axonal fiber myelin sheath) were measured. g-ratio (diameter of axonal fiber / total diameter of axon) and percentage of myelinated axons were calculated (n=3 for 4 group) (B, C). MBP and β-actin in brain homogenates were assayed by Western blotting (D, E) (Con: n=4; 2VO: n=5; 2VO+EGB761: n=6; EGB761: n=5).