Research Paper Volume 13, Issue 3 pp 3218—3238

Brain microstructure mediates sex-specific patterns of cognitive aging

Correlations between cortical gray matter microstructure and cognitive function in regions demonstrating significant differences in correlation strength between men and women. Correlations between RSI metrics and cognitive test scores (residuals after adjustment for education using linear regression), are shown for women and men. Data are shown only for regions in which correlations were moderate for either women or men (r>0.30) and differed in strength between sexes (pppp

Figure 2. Correlations between cortical gray matter microstructure and cognitive function in regions demonstrating significant differences in correlation strength between men and women. Correlations between RSI metrics and cognitive test scores (residuals after adjustment for education using linear regression), are shown for women and men. Data are shown only for regions in which correlations were moderate for either women or men (r>0.30) and differed in strength between sexes (p<0.05, Fisher r-to-z transformation). For Trails B, lower scores indicate better performance. (BDR, Buschke delayed recall; HI, hindered isotropic; IF, isotropic free water; ND, neurite density; VRD, visual reproduction delayed recall) * p<0.05, ** p<0.01, *** p<0.001.