Research Paper Volume 13, Issue 5 pp 7120—7132

Hypoxic pancreatic stellate cell-derived exosomal mirnas promote proliferation and invasion of pancreatic cancer through the PTEN/AKT pathway

Hypoxic PSC-derived exosomal miR-4465 and miR-616-3p act on PC cells to stimulate proliferation. PANC-1 and MIA PaCa-2 cells were treated with exosomes secreted from hypoxic or normoxic PSCs. EV-depleted complete medium was used as control. (A) RT-qPCR analysis of miR-4465 and miR-616-3p expression in PC cells. (B) CCK-8 proliferation assay results. *P

Figure 2. Hypoxic PSC-derived exosomal miR-4465 and miR-616-3p act on PC cells to stimulate proliferation. PANC-1 and MIA PaCa-2 cells were treated with exosomes secreted from hypoxic or normoxic PSCs. EV-depleted complete medium was used as control. (A) RT-qPCR analysis of miR-4465 and miR-616-3p expression in PC cells. (B) CCK-8 proliferation assay results. *P<0.05; **P<0.01.