Research Paper Volume 13, Issue 5 pp 7199—7210

APDL1-CART cells exhibit strong PD-L1-specific activity against leukemia cells

aPDL1-CART cells display PDL1-specific activity against PD-L1-expressing leukemia cells. (A) Analysis of the cytotoxicity of control T cells and aPDL1-CART cells against control and PD-L1-expressing leukemia cell lines following co-culture for 24 h; * P B) Flow cytometry detection of PD-L1 expression in PD-L1-transduced and control leukemia cells. (C) Transmitted light and fluorescence microscopy imaging of aPDL1-CART cells co-cultured with leukemia cells for 24 h (200×).

Figure 5. aPDL1-CART cells display PDL1-specific activity against PD-L1-expressing leukemia cells. (A) Analysis of the cytotoxicity of control T cells and aPDL1-CART cells against control and PD-L1-expressing leukemia cell lines following co-culture for 24 h; * P < 0.05. (B) Flow cytometry detection of PD-L1 expression in PD-L1-transduced and control leukemia cells. (C) Transmitted light and fluorescence microscopy imaging of aPDL1-CART cells co-cultured with leukemia cells for 24 h (200×).