Research Paper Volume 13, Issue 5 pp 7211—7227

Follistatin-like 1 deficiency impairs T cell development to promote lung metastasis of triple negative breast cancer

Fstl1+/- tumor free mice showed a decrease of T cells in periphery. (A) Representative flow cytometry profiles presenting the proportions of CD4+ and CD8+ T cells in the WT and Fstl1+/- mouse lungs. Quantification of the proportions of CD4+ and CD8+ T cells within the gated live cells in the lung tissues of WT and Fstl1+/- mice (n=6, WT; n=7, Fstl1+/-). (B) Representative flow cytometry profiles presenting the proportions of CD4+ and CD8+ T cells in the WT and Fstl1+/- mouse peripheral blood. Quantification of the proportions of CD4+ and CD8+ T cells within the gated live cells in the WT and Fstl1+/- mouse peripheral blood (n=5, WT; n=6, Fstl1+/-). Data presented as mean ± SD. Each dot in the graphs represents an individual mouse. *p p

Figure 3. Fstl1+/- tumor free mice showed a decrease of T cells in periphery. (A) Representative flow cytometry profiles presenting the proportions of CD4+ and CD8+ T cells in the WT and Fstl1+/- mouse lungs. Quantification of the proportions of CD4+ and CD8+ T cells within the gated live cells in the lung tissues of WT and Fstl1+/- mice (n=6, WT; n=7, Fstl1+/-). (B) Representative flow cytometry profiles presenting the proportions of CD4+ and CD8+ T cells in the WT and Fstl1+/- mouse peripheral blood. Quantification of the proportions of CD4+ and CD8+ T cells within the gated live cells in the WT and Fstl1+/- mouse peripheral blood (n=5, WT; n=6, Fstl1+/-). Data presented as mean ± SD. Each dot in the graphs represents an individual mouse. *p < 0.05, ***p < 0.001.