Research Paper Volume 13, Issue 5 pp 7314—7329

Levodopa affects spike and local field synchronisation in the pedunculopontine nucleus of a rat model of Parkinson’s disease

Phase-lock between spikes and local field potential (LFP) in the pedunculopontine nucleus (PPN). (A) Statistical results of phase-lock obtained with resting Type A neurones. (B) Statistical results of phase-lock obtained with resting Type B neurones. (C) Rose histograms representing the distribution of spike phase angles with oscillation in noticeably altered bands. The circles around the histograms display the phase orientation for each discharge, and the red lines arising from the centre indicate the length and vector of the mean phase angles. (D) Statistical results of phase-lock obtained with Type A neurones of rats in locomotion state. (E) Statistical results of phase-lock obtained with Type B neurones of rats in locomotion state. **p

Figure 6. Phase-lock between spikes and local field potential (LFP) in the pedunculopontine nucleus (PPN). (A) Statistical results of phase-lock obtained with resting Type A neurones. (B) Statistical results of phase-lock obtained with resting Type B neurones. (C) Rose histograms representing the distribution of spike phase angles with oscillation in noticeably altered bands. The circles around the histograms display the phase orientation for each discharge, and the red lines arising from the centre indicate the length and vector of the mean phase angles. (D) Statistical results of phase-lock obtained with Type A neurones of rats in locomotion state. (E) Statistical results of phase-lock obtained with Type B neurones of rats in locomotion state. **p < 0.01 relative to control rats; #p < 0.05 relative to lesioned rats.