Research Paper Volume 13, Issue 5 pp 7397—7415

Prognostic significance of epigenetic regulatory gene expression in patients with non-small-cell lung cancer

Epigenetic regulatory gene expression in different types of cancers. The expression levels of epigenetic regulatory genes in tumor and corresponding normal tissues from different cancer types in the Oncomine database. The differences between tumor tissues and corresponding normal tissues were compared using Student's t-test. Note: The cut-off values were p ≤ 0.01, fold change ≥ 2.0, and gene rank ≥ 10%. The mRNA levels of the seven epigenetic regulatory genes were higher in NSCLC tissues compared to the normal lung tissues.

Figure 1. Epigenetic regulatory gene expression in different types of cancers. The expression levels of epigenetic regulatory genes in tumor and corresponding normal tissues from different cancer types in the Oncomine database. The differences between tumor tissues and corresponding normal tissues were compared using Student's t-test. Note: The cut-off values were p ≤ 0.01, fold change ≥ 2.0, and gene rank ≥ 10%. The mRNA levels of the seven epigenetic regulatory genes were higher in NSCLC tissues compared to the normal lung tissues.