Figure 10. Elevated expression of circ_0000527 promoted secretion of inflammatory mediators through regulating ARL2. (A) The knockdown of ARL2 suppressed IL-1β expression in circ_0000527-overexpressing MG-63 cells. (B) The expression of IL-6 was assessed by ELISA. (C) The expression of IL-8 was assessed by ELISA. (D) The expression of TNF-α was assessed by ELISA. ** p<0.01, ***p<0.001.