Ectopic expression of circ_0000527 promoted cell growth and cycle via modulating miR-646. (A) The level of CDK2 was measured by a qRT-PCR assay. (B) The expression of ki-67 was determined using a qRT-PCR assay. (C) Cell growth was assessed by CCK-8 analysis. (D) Cell cycle progression was determined by flow cytometry. *p<0.05, ** p<0.01, ***p<0.001.