Research Paper Volume 13, Issue 4 pp 6115—6133

Figure 5. Expression of let-7e affected the growth and proliferation of HCC cells. (A) Results of cell viability assays showed that upregulated let-7e promoted the proliferation of HepG2 and Hep3B HCC cells. (B) Colony formation assays revealed that upregulated let-7e improved the colony formation efficiency of HepG2 and Hep3B HCC cells. (C) Downregulated let-7e inhibited the proliferation of HepG2 and Hep3B HCC cells. (D) Downregulated let-7e inhibited the colony formation efficiency of HepG2 and Hep3B HCC cells (*P<0.05, **P<0.01, ***P<0.001). NC mimic–transfected and NC inhibitor–transfected cells were the control group in all experiments.