Research Paper Volume 13, Issue 6 pp 8115—8126

Circular RNA RHOT1 promotes progression and inhibits ferroptosis via mir-106a-5p/STAT3 axis in breast cancer

CircRHOT1 promotes proliferation and inhibits apoptosis of breast cancer cells. (A) The MDA-MB-231 cells were treated with control shRNA or circRHOT1 shRNA. The expression of circRHOT1 was measured by qPCR in the cells. (B–G) The MDA-MB-231 and T47D cells were treated with control shRNA or circRHOT1 shRNA. (B, C) The cell viability was measured by the MTT assays in the cells. (D, E) The cell proliferation was analyzed by the colony formation assays in the cells. (F, G) The cell apoptosis was assessed by flow cytometry analysis in the cells. Data are presented as mean ± SD. Statistic significant differences were indicated: ** P

Figure 1. CircRHOT1 promotes proliferation and inhibits apoptosis of breast cancer cells. (A) The MDA-MB-231 cells were treated with control shRNA or circRHOT1 shRNA. The expression of circRHOT1 was measured by qPCR in the cells. (BG) The MDA-MB-231 and T47D cells were treated with control shRNA or circRHOT1 shRNA. (B, C) The cell viability was measured by the MTT assays in the cells. (D, E) The cell proliferation was analyzed by the colony formation assays in the cells. (F, G) The cell apoptosis was assessed by flow cytometry analysis in the cells. Data are presented as mean ± SD. Statistic significant differences were indicated: ** P < 0.01.