Research Paper Volume 13, Issue 5 pp 7517—7537

Molecular characterization of long-term survivors of hepatocellular carcinoma

The upregulation of cell cycle pathways was associated with a poor prognosis in HCC patients. (A, C) Unsupervised hierarchical clustering with Euclidean distances and Ward linkages of the expression matrices of 300 mitotic cell cycle genes in Reactome (A) and 108 cell cycle G1/S phase transition genes in the GO resource (C) for 108 tumor samples (68 STS and 40 LTS). Rows indicate the genes and columns indicate the patients. The patient survival status for each tumor is depicted directly above each column. Cluster I expressed higher levels of the genes in these two pathways, while cluster II expressed lower levels. (B) Kaplan-Meier curves for the clusters resulting from the unsupervised hierarchical clustering in (A). (D) Kaplan-Meier curves for the clusters resulting from the unsupervised hierarchical clustering in (C).

Figure 3. The upregulation of cell cycle pathways was associated with a poor prognosis in HCC patients. (A, C) Unsupervised hierarchical clustering with Euclidean distances and Ward linkages of the expression matrices of 300 mitotic cell cycle genes in Reactome (A) and 108 cell cycle G1/S phase transition genes in the GO resource (C) for 108 tumor samples (68 STS and 40 LTS). Rows indicate the genes and columns indicate the patients. The patient survival status for each tumor is depicted directly above each column. Cluster I expressed higher levels of the genes in these two pathways, while cluster II expressed lower levels. (B) Kaplan-Meier curves for the clusters resulting from the unsupervised hierarchical clustering in (A). (D) Kaplan-Meier curves for the clusters resulting from the unsupervised hierarchical clustering in (C).