Research Paper Volume 13, Issue 5 pp 7517—7537

Molecular characterization of long-term survivors of hepatocellular carcinoma

The expression of eight G1/S phase transition inducers and TP53 mutations predicted survival in the ICGC dataset. (A) Kaplan-Meier curve and log-rank test for HCC patients based on the expression of the eight G1/S phase transition inducers. (B) Kaplan-Meier curve and log-rank test for HCC patients based on the TP53 mutational status and the expression of CDK2 and E2F1. The patients were stratified into the high expression group and the low expression group according to the median of normalized RNA-seq data. The patients were stratified into mutant TP53 group and wild type TP53 group according to TP53 mutational status.

Figure 6. The expression of eight G1/S phase transition inducers and TP53 mutations predicted survival in the ICGC dataset. (A) Kaplan-Meier curve and log-rank test for HCC patients based on the expression of the eight G1/S phase transition inducers. (B) Kaplan-Meier curve and log-rank test for HCC patients based on the TP53 mutational status and the expression of CDK2 and E2F1. The patients were stratified into the high expression group and the low expression group according to the median of normalized RNA-seq data. The patients were stratified into mutant TP53 group and wild type TP53 group according to TP53 mutational status.