Figure 8. Abemaciclib substantially inhibited the proliferation of HCC cells in vivo. (A) Phenotypes of tumors derived from Hep3B cells in mice treated with the vehicle (DMSO) or abemaciclib. (B) The weights of Hep3B cell tumors were detected in mice treated with the vehicle or abemaciclib. (C) The dynamics of tumor development in mice treated with the vehicle or abemaciclib. The tumor volumes were measured as follows: Volume = length*width*width/2. Measurements were taken at the indicated time points. For (B, C), * was compared with Control (***, P < 0.001).