Research Paper Volume 13, Issue 4 pp 4881—4894

MiR-141-3p promotes mitochondrial dysfunction in ovariectomy-induced sarcopenia via targeting Fkbp5 and Fibin

OVX induces sarcopenic obesity in mice. (A) Change of body weight during the experimental period. (B) Body weight gain of Sham and OVX mice after 15 weeks. (C) Average forelimb grip strength in Sham and OVX mice normalized by body weight. (D) Comparison of OVX muscle mass with Sham. (E) Relative mRNA expression of myogenin. Data are means ± SEM. *PPF) Protein expression of genes related to muscle type transition (total MHC, MHC 1, MHC IIa, and MHC IIb) and muscle atrophy (Atrognin-1 and MuRF1).

Figure 1. OVX induces sarcopenic obesity in mice. (A) Change of body weight during the experimental period. (B) Body weight gain of Sham and OVX mice after 15 weeks. (C) Average forelimb grip strength in Sham and OVX mice normalized by body weight. (D) Comparison of OVX muscle mass with Sham. (E) Relative mRNA expression of myogenin. Data are means ± SEM. *P<0.05, **P<0.01; unpaired two-tailed Student’s t-test. (F) Protein expression of genes related to muscle type transition (total MHC, MHC 1, MHC IIa, and MHC IIb) and muscle atrophy (Atrognin-1 and MuRF1).