Research Paper Volume 13, Issue 6 pp 8127—8145

Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury

The molecular mechanism of astrocyte-secreted EVs enriched with NKILA in TBI. Astrocytes secrete EVs to stimulate NKILA expression in neurons, which upregulates NLRX1 by competitively binding to miR-195 and prevents neuronal injury following TBI.

Figure 9. The molecular mechanism of astrocyte-secreted EVs enriched with NKILA in TBI. Astrocytes secrete EVs to stimulate NKILA expression in neurons, which upregulates NLRX1 by competitively binding to miR-195 and prevents neuronal injury following TBI.