Research Paper Volume 13, Issue 5 pp 7570—7588

Low expression of NLRP1 is associated with a poor prognosis and immune infiltration in lung adenocarcinoma patients

Correlations of NLRP1 expression with immune infiltration levels in LUAD. (A, B) The expression levels of NLRP1 in the TCGA-LUAD and GSE72094 datasets had significant positive correlations with the infiltration levels of B cells, CD4 T cells, CD8 T cells, dendritic cells, macrophages and neutrophils. (C, D) The expression of NLRP1 had a significant positive correlation with the immune score of LUAD samples based on the ESTIMATE algorithm in the TCGA-LUAD and GSE72094 datasets. (E, F) Kaplan-Meier survival curve analysis showed that patients with a higher immune score had longer overall survival time than those with a lower immune score in the TCGA-LUAD and GSE72094 datasets. (G, H) Kaplan-Meier survival curve analysis showed that patients with a higher NLRP1 expression level had longer overall survival time than those with a low expression level in the TCGA-LUAD and GSE72094 datasets.

Figure 5. Correlations of NLRP1 expression with immune infiltration levels in LUAD. (A, B) The expression levels of NLRP1 in the TCGA-LUAD and GSE72094 datasets had significant positive correlations with the infiltration levels of B cells, CD4 T cells, CD8 T cells, dendritic cells, macrophages and neutrophils. (C, D) The expression of NLRP1 had a significant positive correlation with the immune score of LUAD samples based on the ESTIMATE algorithm in the TCGA-LUAD and GSE72094 datasets. (E, F) Kaplan-Meier survival curve analysis showed that patients with a higher immune score had longer overall survival time than those with a lower immune score in the TCGA-LUAD and GSE72094 datasets. (G, H) Kaplan-Meier survival curve analysis showed that patients with a higher NLRP1 expression level had longer overall survival time than those with a low expression level in the TCGA-LUAD and GSE72094 datasets.