Research Paper Volume 13, Issue 4 pp 6182—6193

Dexmedetomidine reverses MTX-induced neurotoxicity and inflammation in hippocampal HT22 cell lines via NCOA4-mediated ferritinophagy

DEX modulated the expression of ferritinophagy related protein in HT22 cells with MTX stimulation. (A) Quantitative results of NCOA4, FTH1 (B) and LC3II/I (C) expression in HT22 cells with different treatments. n=3; #pD) Western blot assay and representative results of NCOA4, FTH1 and LC3II/I in HT22 cells with different treatments.

Figure 3. DEX modulated the expression of ferritinophagy related protein in HT22 cells with MTX stimulation. (A) Quantitative results of NCOA4, FTH1 (B) and LC3II/I (C) expression in HT22 cells with different treatments. n=3; #p<0.05, vs Control; *p<0.05, vs MTX group. (D) Western blot assay and representative results of NCOA4, FTH1 and LC3II/I in HT22 cells with different treatments.