Research Paper Volume 13, Issue 5 pp 7589—7607

Fecal microbiota transplantation mitigates vaginal atrophy in ovariectomized mice

Differential microbial categories in fecal microbiota lavage mice and normal saline lavage mice. (A) Phylum-Firmicutes (one-way ANOVA, F3, 37=8.16, PB) Phylum-Proteobacteria (one-way ANOVA, F3, 37=8.16, PC) Phylum-Verrucomicrobia (one-way ANOVA, F3, 37=5.78, P<0.01); Class-Verrucomicrobiae (one-way ANOVA, F3, 37=5.78, P<0.01); Order-Verrucomicrobiales (one-way ANOVA, F3, 37=5.78, P<0.01); Family-Verrucomicrobiaceae (one-way ANOVA, F3, 37=5.78, P<0.01); Genus-Akkermansia (one-way ANOVA, F3, 37=5.78, P<0.01); Species-Akkermansia

Figure 6. Differential microbial categories in fecal microbiota lavage mice and normal saline lavage mice. (A) Phylum-Firmicutes (one-way ANOVA, F3, 37=8.16, P<0.001); (B) Phylum-Proteobacteria (one-way ANOVA, F3, 37=8.16, P<0.001); (C) Phylum-Verrucomicrobia (one-way ANOVA, F3, 37=5.78, P<0.01); Class-Verrucomicrobiae (one-way ANOVA, F3, 37=5.78, P<0.01); Order-Verrucomicrobiales (one-way ANOVA, F3, 37=5.78, P<0.01); Family-Verrucomicrobiaceae (one-way ANOVA, F3, 37=5.78, P<0.01); Genus-Akkermansia (one-way ANOVA, F3, 37=5.78, P<0.01); Species-Akkermansia_muciniphila (one-way ANOVA, F3, 37=5.78, P<0.01); (D) Class-Clostridia (one-way ANOVA, F3, 37=5.88, P<0.01); Order-Clostridiales (one-way ANOVA, F3, 37=5.88, P<0.01); (E) Order-Desulfovibrionales (one-way ANOVA, F3, 37=5.92, P<0.01); (F) Family-Lachnospiraceae (one-way ANOVA, F3, 37=5.18, P<0.01); (G) Family-Ruminococcaceae (one-way ANOVA, F3, 37=6.42, P=0.001); (H) Genus-AF12 (one-way ANOVA, F3, 37=7.17, P=0.001); (I) Genus-Bacteroides (one-way ANOVA, F3, 37=4.09, P<0.05); (J) Genus-Coprococcus (one-way ANOVA, F3, 37=3.59, P<0.05); (K) Genus-Oscillospira (one-way ANOVA, F3, 37=6.24, P<0.01); (L) Genus-Ruminococcus (one-way ANOVA, F3, 37=11.86, P<0.001); (M) Species-Akkermansia_muciniphila (one-way ANOVA, F3, 37=5.78, P<0.01). Data are relative abundances of certain bacterium (percentage of certain bacterium among all fecal bacteria in a mouse) and presented as mean ± SEM, n=11 for OVX+FMT group and OVX+NST group respectively, n=10 for Sham+FMT group and n=9 for Sham+NST group, *P < 0.05, **P < 0.01.