Research Paper Volume 13, Issue 3 pp 3269—3289

Geroprotective effects of Alzheimer’s disease drug candidates

J147 and CMS121 elicit tissue-specific effects in aged SAMP8 brain and kidney. Heatmap of normalized protein levels in brain and kidney of old untreated and old compound-treated SAMP8 mice. Each non-phosphorylated protein was first normalized to beta-actin and then to its level in the same tissue of young mice. Phosphorylated proteins were first normalized to the total amount of the same non-phosphorylated protein and then to its level in young mice. Blue represents decreased protein levels, red represents increased protein levels, and white represents no change in protein level when compared to young mice. RIG-1 expression was not detectable in brain tissue (black). Mean data are presented (n = 4-6/group).

Figure 3. J147 and CMS121 elicit tissue-specific effects in aged SAMP8 brain and kidney. Heatmap of normalized protein levels in brain and kidney of old untreated and old compound-treated SAMP8 mice. Each non-phosphorylated protein was first normalized to beta-actin and then to its level in the same tissue of young mice. Phosphorylated proteins were first normalized to the total amount of the same non-phosphorylated protein and then to its level in young mice. Blue represents decreased protein levels, red represents increased protein levels, and white represents no change in protein level when compared to young mice. RIG-1 expression was not detectable in brain tissue (black). Mean data are presented (n = 4-6/group).