Research Paper Volume 13, Issue 3 pp 3269—3289

Geroprotective effects of Alzheimer’s disease drug candidates

J147 and CMS121 preferentially reverse age-associated protein level alterations in the kidney involved in inflammation, along with alterations to the MAPK and AMPK pathways. Bar graphs of kidney protein levels in young, old untreated, and old compound-treated SAMP8 mice. Data are presented as mean ± SEM (n = 5-6/group). Results were compared by one-way ANOVA, followed by Turkey’s multiple comparison test. Cross symbols represent significance when comparing 3 groups in ANOVA, excluding the unmarked treatment group from the analysis.

Figure 5. J147 and CMS121 preferentially reverse age-associated protein level alterations in the kidney involved in inflammation, along with alterations to the MAPK and AMPK pathways. Bar graphs of kidney protein levels in young, old untreated, and old compound-treated SAMP8 mice. Data are presented as mean ± SEM (n = 5-6/group). Results were compared by one-way ANOVA, followed by Turkey’s multiple comparison test. Cross symbols represent significance when comparing 3 groups in ANOVA, excluding the unmarked treatment group from the analysis.