Research Paper Volume 13, Issue 6 pp 8320—8334

Celecoxib alleviates zinc deficiency-promoted colon tumorigenesis through suppressing inflammation

ZD promoted intestinal tumorigenesis in Apcmin/+ mice. (A) The tumor number in the small intestine and colon was calculated after 60 days of ZD or ZS diet fed. (a) Representative images of tumor in the distal small intestine. (b) Average tumor number is in the small intestine of per mouse. (c) Representative image of tumors in the colon. Numbers of tumors from the small intestine per mouse, each point represented one mouse. (d) Average tumor number is in the colon per mouse. Horizontal bars indicated the average number. (B) Effects of ZD on the tumor multiplicity in small intestine and colon of Apcmin/+. (a) Tumor number in proximal, middle, and distal small intestine was evaluated. (b) Tumor number in small intestine according to size was analyzed. (c) Tumor incidence of the colon in ZD and ZS groups was calculated. (d) Tumor number in colon according to size was analyzed. Data are shown as mean ±S.E.M., n=15. *P P

Figure 2. ZD promoted intestinal tumorigenesis in Apcmin/+ mice. (A) The tumor number in the small intestine and colon was calculated after 60 days of ZD or ZS diet fed. (a) Representative images of tumor in the distal small intestine. (b) Average tumor number is in the small intestine of per mouse. (c) Representative image of tumors in the colon. Numbers of tumors from the small intestine per mouse, each point represented one mouse. (d) Average tumor number is in the colon per mouse. Horizontal bars indicated the average number. (B) Effects of ZD on the tumor multiplicity in small intestine and colon of Apcmin/+. (a) Tumor number in proximal, middle, and distal small intestine was evaluated. (b) Tumor number in small intestine according to size was analyzed. (c) Tumor incidence of the colon in ZD and ZS groups was calculated. (d) Tumor number in colon according to size was analyzed. Data are shown as mean ±S.E.M., n=15. *P < 0.05, **P < 0.01 and ***P < 0.001 vs ZS group.