Research Paper Volume 13, Issue 6 pp 8320—8334

Celecoxib alleviates zinc deficiency-promoted colon tumorigenesis through suppressing inflammation

ZD induced mRNA expression of pro-inflammatory mediators in the colon of Apcmin/+ mice. (A) Expression of C-C motif chemokines mRNAs: CCL1, CCL2, CCL3, CCL4, and CCL5. (B) Expression of C-X-C motif chemokines mRNAs: CXCL1, CXCL2, CXCL3, CXCL5, and CXCL12. (C) Expression of interleukin mRNA: IL-1β, IL-2, IL-4, IL-6 and IL-12, and TNF-α. (D) Expression of COX-2, CXCR2, and CXCR4. Data are shown as mean ±S.E.M., n=6. *P P

Figure 3. ZD induced mRNA expression of pro-inflammatory mediators in the colon of Apcmin/+ mice. (A) Expression of C-C motif chemokines mRNAs: CCL1, CCL2, CCL3, CCL4, and CCL5. (B) Expression of C-X-C motif chemokines mRNAs: CXCL1, CXCL2, CXCL3, CXCL5, and CXCL12. (C) Expression of interleukin mRNA: IL-1β, IL-2, IL-4, IL-6 and IL-12, and TNF-α. (D) Expression of COX-2, CXCR2, and CXCR4. Data are shown as mean ±S.E.M., n=6. *P < 0.05, **P < 0.01 and ***P < 0.001 vs ZS group.